Naloxone for eye pain?

I recently read a review article about management of dry eye-related pain. Some people have pain that is very similar to dry eye pain, but their eyes don’t appear to be that dry and they don’t respond well to conventional treatment for dry eye. Sometimes, this has to do with “over sensitive” nerves. It is a dysfunction of the nervous system, in which affected people feel more discomfort than the rest of the population. One of the proposed treatments is low dose Naloxone, which is usually thought of as working against opioids (i.e. it is often used for people who have had an opioid overdose). The dose is, as stated, low–it is less than one tenth of the dose that can be used against opioids. There’s not a whole lot of other literature out there supporting the use of oral Naloxone to treat ocular symptoms, but it is a reminder that sometimes medicines can be used for lots of different purposes!