Recently, I learned that some corneal surgeons recommend that their corneal transplant patients increase their steroid eye drops around the time of a flu vaccination. It seems like there is no established/well-studied connection between flu shots and transplant rejection, but there are some reports. I think that it is certainly reasonable to increase steroid eye drops around the time of a flu vaccine. One important caveat here: it is not recommended to avoid the vaccine. It may be reasonable to use increased steroids around the time of the vaccine, but it is not recommended to avoid the vaccine due to a possible increased risk of rejection.